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Colorado Mycobacteria Conference 2022: Focus on NTM
Tuesday May 31 – Friday June 3, 2022

Symposium on Environmental Risks for Nontuberculous Mycobacterial Lung Infections
Saturday June 4, 2022

Tuesday May 31, 2022 [5:00 – 9:00 pm]

5:00 – 6:30 pm Registration desk opens, packet pickup

5:00 – 6:30 pm Welcome Cocktails and Hot Appetizers

Welcome and Keynote Lectures
Discussion Leader: Charles L. Daley (National Jewish Health)

6:30 – 6:45 pm Patrick Brennan (Colorado State University, Fort Collins, CO) – Welcome Address
6:45 – 7:20 pm  Anne E. O’Donnell (Georgetown University, Washington D.C.) – “Clinical overview of NTM lung infections”

7:20 – 7:50 pm Break 

7:50 – 8:20 pm Joseph O. Falkinham, III (Virginia Tech, Blacksburg, VA) – “Nontuberculous Mycobacteria in the Environment”

Wednesday June 1, 2022

Session 1: Epidemiology and Clinical Aspects of NTM Diseases
Discussion Leader: Jerry A. Nick (National Jewish Health, Denver, CO)

8:00 – 8:05 am Introduction by Discussion Leader
8:05 – 8:35 am Rebecca Prevots (NIH/NIAID, Bethesda, MD) – “Epidemiology of NTM in the US and Globally”
8:35 – 9:05 am Stacey Martiniano (Children’s Hospital Colorado, Aurora, CO) – ““Clinical manifestations of NTM infection with a focus on the cystic fibrosis population”
9:10 – 9:40 am Amy Leitman (President; NTMir, Miami, FL) – “NTM Lung Disease: Patient Preferences and Experiences”
9:40 – 10:00 am Heather R. Jordan (Mississippi State University, Starkville, MS) –Mycobacterium ulcerans: Tracking transmission”

10:00 – 10:30 am Coffee Break

Session 2: Diagnostics and Biomarkers
Discussion Leader: Delphi Chatterjee (Colorado State University, Fort Collins, CO)

10:30 – 11 am Jerry A. Nick (National Jewish Health, Denver, CO) – “Culture-independent markers of NTM lung disease”
11 – 11:40 am Short talks selected from abstracts:

    •  11- 11:20 am Lucas Boeck (University of Basel, Basel, Switzerland) – “Mycobacterium abscessus killing profiles reveal clinical outcomes independent of drug resistance”
    • 11:20 – 11:40 am Richard Robinson (The Ohio State University, Columbus, OH) – “Immune biogeography of nontuberculous mycobacteria (NTM) infected airways in people with cystic fibrosis (PwCF)”

11:40 am – 12:10 pm Jakko van Ingen (Radboud University Medical Center, The Netherlands) – “Drug susceptibility testing of NTM – academic exercise or key biomarker?”

12:10 – 1:30 pm Lunch Break

Session 3: Genetics and Physiology of NTM
Discussion Leader: Mary Jackson (Colorado State University, Fort Collins, CO)

1:30 – 1:35 pm Introduction by Discussion Leader
1:35 – 2:05 pm Luiz Pedro de Carvalho (Francis Crick Institute, London, United Kingdom) – “Macro-evolution as a source of unknown antibiotic resistance determinants”
2:05 – 3:25 pm Short talk selected from abstracts:

    • 2:05 – 2:25 pm Chidiebere Akusobi (Harvard Medical School, Boston, MA) – “High-density transposon mutagenesis in Mycobacterium abscessus identifies an essential penicillin-binding lipo-protein (PBP-lipo) involved in septal peptidoglycan synthesis and antibiotic sensitivity”
    • 2:25 – 2:45 pm Rebecca Davidson (National Jewish Health, Denver, CO) – “Lineage analysis of Mycobacterium abscessus subsp. abscessus isolates from a treatment refractory infection reveals genomic adaptations over a five-year period”
    • 2:45 – 3:05 pm Brittany Ross (Georgia Institute of Technology, Atlanta, GA) – “Identification of molecular determinants that govern morphotype-specific physiology in Mycobacteroides abscessus”
    • 3:05 – 3:25 pm Scarlet Shell (Worcester Polytechnic Institute, Worcester, MA) – “The sRNA B11 controls virulence-associated phenotypes in Mycobacteroides abscessus”

3:30 – 6:00 pm Poster Session & Light Appetizers

Thursday June 2, 2022

Session 4:  Pathogenic Strategies of NTM and Host Immune Response to NTM Infections
Discussion leaders: Mercedes Gonzalez-Juarrero (Colorado State University, Fort Collins, CO); Anil K. Ojha (New York State Department of Health, Wadsworth Center, Albany, NY)

8:00 – 8:05 am Introduction by Discussion Leader (Bacteriology)
8:05 – 8:35 am Andres Floto (University of Cambridge, Cambridge, United Kingdom) – “Understanding how Mycobacterium abscessus causes disease”
8:35 – 9:05 am Laurent Kremer (Institut de Recherche en Infectiologie de Montpellier; CNRS UMR9004, France) – “The virulence determinants of Mycobacterium abscessus infection in zebrafish”
9:05 – 9:25 am Short talk selected from abstracts:

    • Nicola Lore (IRCCS Ospedale San Raffaele, Milan, Italy) – “Unravelling the pathogenicity of Mycobacterium abscessus clinical isolates in CF pulmonary epithelial cell and mouse models of respiratory infection”

9:25 – 9:55 am Laurent Marsollier (Université d’Angers – INSERM, Angers, France) – “New insight on Buruli ulcer physiopathology”

9:55 – 10:25 am Coffee Break

10:25 – 10:30 am Introduction by Discussion Leader (Immunology)
10:30 – 11:00 am Luiz Bermudez (Oregon State University, Corvallis, OR) – “Strategies of Mycobacterium avium and Mycobacterium abscessus to Initiate Airway Infections”
11:00 – 11:30 am Céline Cougoule (IPBS – Toulouse; CNRS-Université Toulouse III, France) – “Human airway organoids for Cystic Fibrosis-driven Mycobacterium abscessus infection modelling”
11:30 – 11:50 am Short talk selected from abstracts:

    • Haleigh Gilliland (Michigan State University, East Lansing, MI) – “Defining complex mechanistic interactions and responses by macrophages during Mycobacterium abscessus infection”

11:50 am – 2:00 pm Lunch Break 

2:00 – 2:30 pm Marcela Henao-Tamayo (Colorado State University, Fort Collins, CO) – “NTM mucosal-induced immune response has an enhanced protective effect on BCG’s efficacy against Mycobacterium tuberculosis infection”
2:30 – 3:10 pm Short talks selected from abstracts:

    • 2:30 – 2:50 pm Elsjee Pienaar (Purdue University, West Lafayette, IN) – “An Agent-Based Model to Assess the Contribution of Menopause-Associated Immunological Changes to Increased Risk of MAC Infection”
    • 2:50 – 3:10 pm Susan Baldwin (Seattle Children’s Research Institute, Seattle, WA) – “Immunogenicity and protection against Mycobacterium avium with a heterologous RNA prime and protein boost vaccine regimen”

3:15 – 5:00 pm Poster session

6:00 – 9:00 pm Gala Dinner at Coopersmith’s (Pool Side)

Friday June 3, 2022

Session 5: Intervention Strategies and Clinical Trials
Discussion leaders: Tiffany Burnett (Cystic Fibrosis Foundation, Bethesda, MD), Barbara E. Laughon (NIH/NIAID, Bethesda, MD)

8:00 – 8:05 am Introduction by Discussion Leaders
8:05 – 8:35 am Martin I. Voskuil (University of Colorado Anschutz School of Medicine, Aurora, CO) – “RS ratio and supporting physiologic assays for mycobacterial drug and regimen evaluation”
8:35 – 9:05 am Rebekah M. Dedrick (Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA) – “Therapeutic potential of phages for mycobacterial infections”
9:05 – 9:25 am Short talk selected from abstracts:

    • Winifred Akwani (University of Surrey, Surrey, United Kindom) – “Understanding antibiotic penetration into mycobacterial biofilms using NanoSIMS”

9:25 – 9:50 am Coffee Break

9:50 – 10:20 am  Thomas Dick (Hackensack Meridian Health, Nutley, NJ) – “Rifamycins for M. abscessus lung disease”
10:20 – 11:00 am Short talks selected from abstracts:

    • 10:20 – 10:40 am Jickky Palmae (Hackensack Meridian Health, Nutley, NJ) – “Mycobacterium tuberculosis DprE1 inhibitor OPC-167832 is active against Mycobacterium abscessus”
    • 10:40 – 11 am Timothy Shaw (Queen’s University Belfast, Belfast, United Kingdom) – “Human mesenchymal stromal cells inhibit Mycobacterium avium growth in in vitro and in vivo models of pulmonary infection

11:00 – 11:30 am Richard E. Lee (St Jude Children’s Research Hospital, Memphis, TN) – “Lessons learned from drugging M. abscessus with spectinomycin analogs”

11:30 – 1:00 pm Lunch Break

1:00 – 1:30 pm Kenneth N. Olivier (NIH/NHLBI, Bethesda, MD) – “NTM trial dilemma: Outcomes assessment in rare disease setting – Who, what, when and how to measure”
1:30 – 2:10 pm Short talks selected from abstracts:

    • 1:30 – 1:50 pm Jason Holder (Endolytix Technology, Beverly, MA) – “Shredding Intracellular NTMs with a Macrophage-Targeted Enzymatic Cocktail”
    • 1:50 – 2:10 pm Andreanne Lupien (McGill International TB Center, Montreal, Canada) – “The arylvinylpiperazine amide AX-35 targets the cytochrome bc1 in Mycobacterium abscessus”

2:15 pm Presentation of Poster Awards

2:30 pm Closing Remarks

Environmental Risks for Nontuberculous Mycobacterial Lung Infections Symposium

Saturday June 4, 2022 [8:00 am – 3:00 pm]

Session 1: Environmental Sampling, Household Sampling, and Laboratory Techniques
Discussion leaders: Noah Fierer (University of Colorado, Boulder), Max Salfinger (University of South Florida)

8:00 – 8:10 am D. Rebecca Prevots (NIH), Welcome and Introduction
8:10 – 8:30 am Matthew Gebert (University of Colorado, Boulder) – “Predicting the environmental preferences of NTM”
8:30 – 8:50 am Jennifer R. Honda (National Jewish Health) – “Guess what? We can see you! – Environmental NTM in man-made and natural sites of Hawai’i”
8:50 – 9:10 am Jerry Cangelosi (University of Washington) – “NTM Exposures and Sources of Infection in Home Environments”
9:10 – 9:30 am Janet Stout (Special Pathogens Laboratory) – “Evaluation of new culture medium for water samples”
9:30 – 9:50 am Ted Marras (University Health Network, Canada) – “Water quality attributes and pulmonary NTM infection in Ontario, Canada”

10:00 – 10:25 am Coffee Break

Session 2: Epidemiologic and Statistical Approaches for Estimating Environmental and Climatic Risks for NTM
Discussion leaders: D. Rebecca Prevots (NIH), Rachel Mercaldo (NIAID)

10:25 – 10:30 am Introduction by Discussion Leaders
10:30 – 10:50 Rachel Thomson (University of Queensland, Australia) – “Geospatial analysis of NTM risk in Queensland, Australia”
10:50 – 11:10 Ettie Lipner (NIAID) – “Water quality risk factors for NTM infection among US CF patients”
11:10 – 11:30 Kozo Morimoto (Fukujuji Hospital, Japan) – “NTM and the environment—Japanese perspectives on home and natural environments”
11:30 – 11:50 Joshua French (University of Colorado, Denver) – “Spatial scan methods for disease cluster detection”

12:00 – 1:30 pm Lunch and Poster Session
Moderator: Julia Marshall (NIH)

1:30 – 2:10 pm Panel Discussion 1: Sampling and culturing methods for NTM
Discussion moderators: Noah Fierer (University of Colorado, Boulder), Max Salfinger (University of South Florida)

2:10 – 2:20 Break 

2:20 – 3:00 pm Panel Discussion 2: Statistical and analytic challenges in estimating NTM risk
Discussion moderators: Joshua French (University of Colorado, Denver), Rachel Mercaldo (NIAID)